I read a handful of comic-book reprints of the strip BIG CHIEF WAHOO-- which began in 1936-- but I was utterly unable to find anything culturally significant, or even just stupidly funny, in the comic adventures of Wahoo, a pint-sized Indian who speaks in native patois and has a hot girlfriend named Minnie-Ha-Cha. One Native American site cleverly coined the term "Poca-hottie" for a hot Indian girl, who was for some reason much more modernized than her backwards boyfriend.
Around 1940 the comedy strip was converted to an adventure concept, in which Wahoo became second banana to handsome journalist Steve Roper, while Minnie-Ha-Cha became Steve's girlfriend. However, both of the Real American characters faded in 1947, though the ROPER strip lasted until 2004.
This Blackthorne volume reprints some of the "straight" adventures of Wahoo and Minnie, which IMO make better reading than the lame comic ones.